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ABOUT NMN


Leading the world to commercialize the "future'' and push it to a new dimension



In 2011, a team led by Professor Shinichiro Imai in the Department of Genetic Biology and Medicine at the Washington University School of Medicine reported that the existence of NMN (abbreviated as NMN, β nicotinamide mononucleotide, β NMN, β NMN, Nicotinamide mononucleotide: a kind of vitamin B3, also contained in natural organisms, coenzyme NAD: nicotinamide adenine dinucleotide, the precursor of nicotinamide adenine dinucleotide, hereinafter referred to as NMN) is showing surprising effect.

NMN is contained in vitamin B3 and exists in all biological cells. Now, the research on NMN continues around the world and has received a lot of attention. NMN is originally a substance produced naturally in the body, and it is said that its ability to be produced in the body gradually decreases with age.




The NMN of MIRAILAB Biosciences is the world's first "academic quality'' NMN



The company’s NMN has been used to carry out the world’s first human safety test, which confirmed the discovery of the Sirtuin gene, the increase of melatonin, and the increase of other growth hormones in the long term (24-week) clinical study conducted by the National University Medical Department. 

Its performance and purity have been highly evaluated. The NMN products donated and provided by the Washington University School of Medicine have been adopted as experimental foods for new clinical studies funded by the U.S. Department of Defense (DOD). Mirailab's NMN is the world's best NMN product. 




The highest purity in the world above 99%



Various research institutions have confirmed the company's NMN to have a purity of more than 99%, and it has also been confirmed that it has the highest degree of safety for humans and rodents. In addition, another company in the world commercializes health foods containing high-purity NMN.


NMN quality refers to the high purity, the reason why it is necessary to pay attention to the small amount of "impurities (mixture)" and the nature of "impurity substances," please pay attention to the following:



 
●Is the "purity" of NMN contained in the NMN matching product indicated correctly? What exactly are the "impurities" contained in NMN?


In today's day and age, when attention to NMN is getting higher and higher, in addition to our company, there are also many NMN hybrid products flooding the world. However, even if it is called an NMN-compatible product, it is necessary to pay full attention to the fact that the quality of NMN used in each product is different.



 ●The problems caused by low purity



Products containing low-purity NMN will inevitably contain many "impurities." It is still unclear what kind of negative effects will be produced when these products containing impurities are used.



As an extreme example, the arsenic milk poisoning incident (1955), in which more than 10,000 people suffered health damage, and more than 100 people were killed, was caused by the additives used as stabilizers contained about 5% of impurities.



Based on these past lessons, the U.S. Food and Drug Administration (FDA) also put forward the suggestion that "for food safety, it is necessary to eliminate as many impurities as possible."



 



●About the NMN purity mark ~Absolute measurement method and relative measurement method.~



Regarding the purity of NMN, some products are labeled as 99.9%, etc. At first glance, it gives the impression of very high purity (fewer impurities). But what does this 99.9% value mean? Is there a clear explanation?



 



●About purity measured by the absolute method



As a reliable and high-purity test method, it is possible to detect "what percentage of NMN is in all substances detected in the raw materials." Purity markings based on this absolute measurement method are our company's definition of purity marking.



 



●About the purity measured by the relativity method



Under normal circumstances, when the testing organization conducts purity inspections when the purity of the "standard NMN raw material" is 100%, this is only a relative value. It is surprising that "as a standard NMN raw material," the manufacturer can provide it by itself, and its purity has not yet been disclosed.






As shown in the figure above, if the purity of the "standard NMN raw material" measured by the absolute method is 95%, and the purity of the NMN of other companies is 94%, the purity by the relative measurement method is 98.9%.




On the other hand, our company's NMN has a purity of 99.8%. If the same relativity measurement method as above is used for inspection, the purity is 105.0%.



In the relative method measurement, the quality of the "standard NMN raw material" is influenced. Therefore, at first, glance, even if it is a good impression, it cannot be said that there are few impurities.



In a best-case scenario, companies can use this fair method to mark purity, but the current situation is that each company does not clearly specify the details of the mark.




●Compare and analyze the purity of NMN according to the absolute measurement method.



The Productive Aging Research Institute (IRPA) of the general social group legal person, the purity of NMN raw materials used by 4 different NMN companies.


The absolute method measurement was performed.


These test results show that our company's NMN has the highest purity and quality globally and can be used with peace of mind.



 

The productive aging research institute (hereinafter referred to as IRPA) of the general corporate legal person, NMN purity of 4 companies has been tested by both LC-UV (※ 1) and NMR (※ 2) methods. The various results of absolute method measurement show that only our company NMN has more than 99% purity.



The results show that the NMN of the other three companies contains a lot of impurities.



※1  LC-UV (High-Performance Liquid Chromatography-Ultraviolet Absorption Spectrometry)



※2  NMR (Nuclear Magnetic Resonance Spectrum)



Please refer to the comparison table below for the NMN samples' LC-UV Analysis and NMR Analysis test results.






●Analysis of impurities contained in NMN



The Productive Aging Research Institute (IRPA) of the General Social Organization (IRPA) evaluated magazine substances in NMN raw materials from NMN companies.



Conducted measurement analysis test.





As with the purity analysis, the LC-UV method is used for the analysis first. The mass spectrometry (MS) test can detect the impurity separation peak used to determine the impurity composition. As a result, in the raw materials of NMN used by the company, only a small amount of "niacinamide" impurities were detected.


The NMN of the four companies contains "niacinamide" as an impurity. It is a nutrient substance called niacin together with niacin in the living body. It is a safe substance that humans can ingest.



On the other hand, the NMN of "OK Company" and "Self-Affirmed GRAS Certified Company" contains many other substances besides "niacinamide" as an impurity substance.



In particular, the NMN of "Self-Affirmed GRAS certified company" contains 6 kinds of impurities in addition to "niacinamide."



Among them, there are unimaginable substances in the living body. Long-term intake of these NMN products containing a large number of impurities may impact the body.



 



It is important to note that even though it is labeled as containing high-purity NMN, what impurities are actually contained in it and products containing NMN with low purity and unconfirmed safety are also on the market.



 



◆Productive aging research organization (IRPA)◆



https://www.irpa.ne.jp/







About the implementation of safety, evaluation, and various other tests conducted by MIRAILAB Biosciences





■Hiroshima University Graduate School of Biomedicine and Health Sciences: Ended on March 31, 2019



Effects of long-term intake of nicotinamide mononucleotide (NMN) on the human body



—No compromise in security



https://upload.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000029616






■Japan Food Analysis Center: Ended on July 30, 2018



・Acute oral toxicity test-no abnormalities or death cases (mice)



・Reverse mutation test-negative (none)



・One-time skin irritation test-no issues detected



・Eyeball irritation test-no irritation detected 






■DRC Corporation: Ended on November 23, 2015



・Foods containing resveratrol and nicotinamide mononucleotide



Experiments on lipid improvement effects by ingesting the composition:



(Clinical research on humans)-There is no problem with safety



 



■Japan Food Analysis Center: Ended on August 17, 2015



・Acute toxicity test-no abnormalities or death cases (mice)



・Reverse mutation test-negative (none)



・One-time skin irritation test-no irritation detected



・Eyeball irritation test-no irritation detected